Women with Myasthenia Gravis Have Poorer Quality of Life, But Thymus Removal Helps, Study Says

Quality of life among myasthenia gravis (MG) patients is worse in women than men, but removing the thymus in women eliminates this disparity, a recent study shows.

The study, “Gender and Quality of Life in Myasthenia Gravis Patients from the Myasthenia Gravis Foundation of America Registry,” appeared in the journal Muscle and Nerve.

Myasthenia gravis is a neuromuscular autoimmune disease in which the immune system produces autoantibodies that attack the connection between the nerve and muscle, called the neuromuscular junction. This leads to muscular weakness and fatigue, causing disability and impaired quality of life.

Researchers believe the thymus, a gland in the chest that regulates the development of a type of immune cell, may trigger or maintain the production of these autoantibodies. Some MG patients show thymus abnormalities, such as tumors or an enlarged gland. Thymus removal in these cases has been shown to improve patients’ clinical outcomes.

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The Hard Truth About My Daughter’s Dyspraxia

As a mom to a recent high school graduate with dyspraxia, I’ve had a front row seat for almost two decades to her struggles. My daughter, Elizabeth, was diagnosed with dyspraxia at 2½. (The term in the DSM-5 is “developmental coordination disorder.”)

Elizabeth’s difficulty with motor skills tasks, like cutting with scissors and buttoning clothes, was obvious from a young age. But over time, we also came to realize she has trouble with executive function and working memory.

It’s been hard to watch her struggle over the years. To cope, she and I have learned to talk about how she’s feeling. We began our “chat” time when she was in grade school. Over time, they’ve grown in length and depth of conversation. We talk a great deal about her daily life—the good and the bad.

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3 Signs Someone Is Suffering From Post Narcissist Stress Disorder (PNSD)

What is Post Narcissist Stress Disorder (PNSD)?

Much like Post Traumatic Stress Disorder, PNSD is a disorder that comes about after one has been living in close proximity to a narcissist. Living with a narcissist can be extremely taxing on a person. Narcissists tend to be extremely manipulative and abusive. They will often gaslight their victims and make everything about their own feelings

After getting free of a narcissist’s influence, people can often experience a period of helplessness, anxiety, anger, or depression, much like what happens after a traumatic event. People with PNSD react much like people who have PTSD. There are three major signs for someone who is suffering from Post Narcissist Stress Disorder.

HERE ARE 3 SIGNS SOMEONE IS SUFFERING FROM POST NARCISSIST STRESS DISORDER

“Trauma is personal. It does not disappear if it is not validated. When it is ignored or invalidated the silent screams continue internally heard only by the one held captive.” – Danielle Bernock

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The Two Things You Need in Order to Avoid EVER Attracting Another Narcissist

Last week, I wrote an article about how obsessively researching narcissism can ruin your life.

A lot of readers said they thought it was the right thing to do, and some shared that they do it because they want to make sure they never attract another narcissist into their lives.

These are common beliefs after finally leaving a relationship with a narcissist.  I get it.  After all the lies and betrayal and trying to gain back some sense of normalcy, the last thing anyone would want is to find themselves in yet another toxic and dysfunctional relationship.

But, in truth, there is only so much you can learn about narcissism.  There may be thousands of blogs out there on the topic, but at a certain point, there’s really nothing new to learn.  The science has been done, the behavior has been analyzed, it’s been described in many different languages, and the internet is over-saturated with content revolving around narcissism.

There may be fifty shades of grey, but at the end of the day, it’s just gray.

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The signs and symptoms of Parkinson’s disease

Parkinson’s disease is a neurological condition with a wide range of effects, including problems with movement, blood pressure and thinking, and mood, sensory, and sleep difficulties.

The symptoms of Parkinson’s disease (PD) usually begin gradually, and they affect each person differently. The symptoms a person has will vary widely, regardless of how severe they are or how quickly they develop.

Read on to find out more about the different types of symptoms and how to recognize the early symptoms of PD.

Early symptoms

Tremor with parkinson's

Around 7 out of 10 people with PD experience tremor at some stage.

The symptoms of PD affect individuals differently, but some can be an early sign of the disease.

These are:

  • REM sleep disorder and other sleep problems
  • the loss of the sense of smell
  • tremor, especially in one hand
  • a smaller size of handwriting
  • difficulty moving or walking or a stooping gait
  • constipation
  • loss of facial expression, that may make the person look emotionless
  • a low or soft voice

 

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What causes a myasthenic crisis? Symptoms, diagnosis, treatment, prevention

Myasthenic crisis is a complication of a condition known as myasthenia gravis, which is characterized by weakness and rapid fatigue of voluntarily controlled muscles. It is considered a neuromuscular autoimmune disease that can affect the muscles of the eyes, face, and eventually other parts of the body.

Suffering from a myasthenia gravis crisis can be an extremely hazardous situation requiring emergency medical assistance. Between one-fifth and one-third of all patients with generalized autoimmune myasthenia gravis can be affected.

Signs and symptoms of myasthenic crisis

Understanding the background of myasthenia gravis will give some context as to how myasthenia gravis with acute exacerbation can lead to a myasthenic crisis. In this condition, antibodies either block or destroy nicotinic acetylcholine receptors at the neuromuscular junction between the nerve and muscle. This structure serves to communicate the control of muscular contraction.

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5 Things to Remember in a Myasthenia Gravis Crisis

June is myasthenia gravis (MG) awareness month. For those that have never heard of this rare, neuromuscular autoimmune disease, here are a few fun facts about it:

1. It can make the body go weak at any time
2. Double vision and droopy eyelids are a key trait
3. Can cause severe fatigue in the neck or limbs
4. Can affect breathing
5. Worsens as muscles are used

If you have MG like me you know that some days are great while others just don’t go as planned. One moment you are on your game and going about your life like the warrior you want to be, the next you are in a myasthenia gravis crisis curled up in fetal position in bed. It’s just the way it goes.

I had one of those moments a couple of days ago. I woke up, ran some errands, got coffee with my daughter, picked up the house, got take out for dinner then sat down to eat as usual then sat down to eat. I could feel myself getting weaker throughout the day but thought I could negotiate my way out of it. The conversation in my head went like this:

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Why Does Pain Get Worse When a Storm Is Coming?

The next time you watch the weather forecast, notice the barometric pressure, measured in inches. Numbers such as 30.04 will be followed by “rising,” “falling,” or “steady.” Typically, when a low pressure front is coming (and they do, all the time) it signals not only a change in the weather, but a drop in the barometric pressure, which is pressure against the Earth’s atmosphere. Remember when Grandma would say, “Rain’s coming, and I can feel it in my joints?” She actually knew this because of what happens to our bodies when the barometric pressure changes.

That means that the pressure against your body drops as well, and your joints and areas that are injured can begin to swell. This swelling causes increased inflammation, and we require hormones to deal with this increased activity in our bodies. Increased use of these hormones can cause depletion of them, too. Our body is not a bottomless pit when it comes to its defense systems.

We have, nestled atop each kidney, a small gland that produces both adrenaline and cortisone. These two hormones help us with energy, mood, immune function, pain management and the famous “Flight or Fight” response. The steroid cortisone is fundamental in managing pain, immune function and energy. When cortisone levels drop, these can all become a problem. Adrenaline is famous for energy and strength. We all know stories of how a man demonstrates sudden superhuman strength when he picks up something heavy like a car, rescuing a child who is trapped underneath. (Don’t try this at home!)

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What Is Myasthenia Gravis? An autoimmune neuromuscular disorder

Myasthenia gravis is an autoimmune neuromuscular disorder. Usually, the body’s immune system makes antibodies to attack germs that invade the body. “Autoimmune” means that a person’s immune system malfunctions and it creates antibodies that attack the person’s own cells. In myasthenia gravis, the antibodies interfere with the transmission of nerve signals to the muscles. In other words, the muscles don’t receive the signal from the nerves to move.

Symptoms

Often, a person will have specific muscle weakness and not overall tiredness or fatigue. The muscles most commonly affected are:

  • Drooping eyelids (first symptom in 2/3 of all patients)
  • Mouth weakness, leading to trouble chewing, swallowing, or talking (first symptom in 1/6 of patients)
  • Arm or leg weakness (less common as a first symptom)

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Honest and Heartfelt Advice for People Newly Diagnosed with Crohn’s Disease

Coming to terms with a Crohn’s disease diagnosis can be tough. The lingering questions, anxiety, and feelings of isolation can be especially challenging. But remember: You have support and are not alone. The Crohn’s & Colitis Foundation estimates that as many as 780,000 people in the United States live with Crohn’s, with upward of 33,000 new cases diagnosed each year.

To help provide some clarity and support, we asked members of our Living with Crohn’s Disease community group what advice they would give to someone just diagnosed with Crohn’s. Now, it should be noted that what works for one person may not be the best option for another. But sometimes, a little bit of support from strangers can make a world of difference.

“From my experience, the beginning part of my Crohn’s journey was the worst, because that’s when I was the sickest and doctors didn’t know what was wrong. But the worst is over and it’s only uphill from there. Keep that in mind while you battle the rough part now; your quality of life can improve!”

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